3/12/2023 0 Comments India ink cryptococcus![]() gattii being able to infect immunocompetent hosts 4, 5. Cryptococcosis affects mostly immunocompromised individuals causing severe lung disease and meningoencephalitis, with C. gattii is generally seen as a tropical or subtropical fungus 1, 2, 3. Both are globally distributed, although C. gattii.Ĭryptococcosis is an infectious disease caused by the fungal species Cryptococcus neoformans and Cryptococcus gattii. gattii, which suggests that the presence of B-1 cells and anti-GXM antibodies is fundamental during the control of infection by C. Thus, the present study strongly points to a higher susceptibility of the XID mouse to C. gattii and the predominant presence of cytokines with a Th2 profile was also observed in these animals. We described an increase in the capsular size of C. In addition to this, we observed an increased fungal load in the blood and in the brain. Our model of chronic lung infection revealed that XID mice, unlike the sufficient group of B-1, had early mortality with significant weight loss, in addition to reduced levels of IgM and IgG specific to GXM isolated from the capsule of C. We use the XID mice compared to BALB/c mice that are sufficient for the B-1 population during C. ![]() In the present study we tried to unravel this issue using XID mice, a murine model deficient in the Btk protein which compromises the development of B-1 lymphocytes. neoformans infection has been initially described, however the role of the humoral response of B-1 cells has not yet been evaluated during C. The humoral response has already been described in limiting the progression of cryptococcosis where the B-1 cell seems to be responsible for producing natural IgM antibodies, crucial for combating fungal infections. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of the disease, meningoencephalitis. Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. ![]()
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